Simon Mendez is a CNRS Researcher (HDR) at the Institute of Montpellier Alexander Grothendieck (IMAG), Université de Montpellier, France. His research bridges computational fluid dynamics (CFD) and biomedical engineering, focusing on the mechanics and dynamics of red blood cells (RBCs). He is the main developer of YALES2BIO, a CFD platform dedicated to the simulation of blood flows and biological fluid mechanics. His work spans fundamental studies of RBC rheology and membrane mechanics, as well as applied research on RBC diagnostics and medical imaging, including virtual Magnetic Resonance Imaging. He has led several projects on RBC deformation and transport, as well as on the modeling of thrombosis and COVID-19 aerosol transmission. His interdisciplinary approach combines advanced numerical methods, fluid–structure interaction, and close collaborations with experimental researchers to address challenges in hemorheology and biomedical applications. Simon Mendez is also co-director of the GDR MECABIO Santé and actively contributes to national and international research networks.