Dr. Michel AURRAND-LIONS PI Team "Leuko/stromal interactions in normal and pathological hematopoiesis", CRCM/UMR1068 Co-head of the IPC/CRCM Experimental Pathology facility (ICEP). Michel Aurrand-Lions, immunologist by training, made seminal contributions to our understanding of adhesive network regulating immune system and haematopoietic homeostasis. He is using mouse models to study bone marrow niche alterations occurring at early stages of acute myeloid leukemia development with single cell technologies and spatial transcriptomics. He reported ligand/receptor pairs involved in hematopoietic stem cell maintenance and identified new biomarkers for acute myeloid leukemia.